Note: While the upper limit of this setting is 0xffffffff (or 4294967295), configuring the server with a value larger than the default will consume additional memory on the server – one new page per connection. If the value is set too high and too many connections are created for each user application instance, the server will run low on memory or become completely unresponsive. The lower default NSPI connection limit in Windows Server 2008 was based on customer experience, where previous operating systems would allow themselves to be overwhelmed by third party products in what amounts to a denial of service attack. Use a common sense approach to increasing beyond the default value; for example, start with decimal 250 (hex 0x000000FA), then test to see the memory overhead created and that the errors have ceased. Your long-term solution must be to contact the vendor of your NSPI product and ask them to change their behavior; the registry value is only as a workaround to provide error relief.
For more information, see the following article from the Microsoft Knowledge Base online: