Some applications may have specific mitigations disabled in the Application Configuration policy in Enhanced Mitigation Experience Toolkit (EMET). These disabled mitigations may not take effect when one or both of the following EMET policies are also enabled:
EMET policies are not cumulative. When Default Protections policies are applied in addition to the Application Configuration policy, duplicate entries for the same application may occur, and you cannot prioritize the Application Configuration settings. For example, because the Default Protections for Popular Software policy enables all mitigations for a set of applications, any of the same applications that are configured through the Application Configuration policy with mitigations disabled will not take effect.